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The Institut Pasteur in Bangui, created in 1961, was born out of an agreement between the Institut Pasteur and the government of the Central African Republic. This institute, officially recognised by the national government as an organisation "d'utilité publique" (beneficial to the public at large), collaborates with the Ministry of Health and International Organisations.

Its main activities include:

  • Public Health - with its laboratory of biomedical analysis, its vaccination center, and its activities as national reference laboratory for various diseases (such as rabies, flu, and measles) and as a WHO regional reference laboratory for Africa on poliomyelitis, the Institut Pasteur in Bangui provides useful public health services for the local population.

  • Education - with its center of information and training, which represents a dedicated place of scientific communication and exchanges for central Africa, the Institut Pasteur in Bangui organises each year, several conferences and workshops on research topics related to public health concerns. It also participates in Bacteriology and Virology university courses for the University of Bangui.

  • Research - in the fields of Microbiology and Medical Entomology on topics that represent health priorities for central Africa (such as: HIV, oncogenic retroviruses, viral hepatitis, haemorrhagic fevers, tuberculosis, malaria, vector-borne and zoonotic diseases, etc.).

In the Central African Republic, meningitis, diarrhea, and respiratory infections represent the main causes of new-born death. However, the proportion due to viral, bacterial, or parasitic causes is still unknown. Moreover, little is known about bacterial resistance to antibiotics. Lobaye, the region chosen for the pilot phase of the project represents a crossroads where antibiotics from Cameroon and Nigeria are mass-marketed. Such a region is highly likely to promote the emergence of multidrug-resistant bacteria.


There does exist some evidence of antibiotic resistanceAntibiotic resistance
Infections caused by antibiotic-resistant bacteria are increasing steadily worldwide in hospitals as well as in the community. These infections often have more severe outcomes than those caused by so called "sensitive" bacteria. As a consequence, they also require more expensive second-line treatments as well as a more careful and costly follow-up care for patients.
in the region as the first emerging strains of Extended Spectrum Beta-Lactamase Enterobacteriaceae (ESBLE) were identified in the Central African Republic at the Institut Pasteur in Bangui in 2003. From January 2003 to March 2005, 17 of these strains were isolated from collected samples. They were associated with several pathologies, such as urinary tract infection, ear or wound infections, and were resistant to all antibiotics available at the country level. During the past 5 years, 10% of the ESBL strains isolated at the Institut Pasteur in Bangui came from patients with community acquired infections.

For the purpose of the pilot phase of the BIRDY project, the Institut Pasteur in Bangui will set up a newborn paediatric cohort in M'baïki, a rural area 60 km from Bangui. There, 500 children will be recruited and followed for 6 months in order to monitor any eventual bacterial infections. Thanks to its on-going participation in a study dealing with severe acute diarrhea, the Institut Pasteur in Bangui has developed significant expertise in clinical research / field epidemiology as well as logistic capacities needed to implement a large paediatric cohort.

The ChARLI project Team

The project team will unite staff from the epidemiology unit and the Laboratory of medical analyses and Molecular Bacteriology which is involved in microbiological diagnosis and Public Health surveys.

The coordinating group at the local level

Dr Thierry Frank, received a thesis in bacteriology and molecular medicine at the University of Paris VI in June 2008. He is head of the Laboratory of medical analyses and Molecular Bacteriology.




(data extracted from the CIA world-fact book)

4,950,027 (July 2011 est.)

Urban population:
39% of total population (2010)

Birth rate:
36.46 births/1,000 population (2011 est.)
/ World ranking: 24

Life expectancy:
total population: 50.07 years
/ World ranking: 214

Infant mortality rate:
total: 99.38 deaths/1,000 live births
country / World ranking: 6

Major infectious diseases:
Degree of risk: very high
Food or waterborne diseases: bacterial and protozoal
diarrhea, Hepatitis A and E, typhoid fever
Vector borne diseases: malaria, yellow fever
Respiratory diseases: meningococcal meningitis
Water contact diseases: schistosomiasis, cholera
Animal contact disease: rabies (2009)
Economy: country comparison by GDP: ranks 171
(purchasing power parity)